General practitioner / Histamine intolerance

A characteristic (or histaminosis) is the intolerance of histamine that we ingest through food. Intolerance is caused by a lack of histamine-degrading enzymes diamine oxidase (DAO) and / or histamine N-methyltransferase (HNMT). This may also be due to a mismatch between histamine uptake and degradation in the body. This theory was developed in the 1980s as part of research into biogenic amines. [1]

According to some authors, histamine intolerance is not a congenital disease, but an acquired disease. It affects almost 1% of the European population. [2] [3] 80% of sick patients are middle-aged women. The symptoms of the disease may disappear during pregnancy, but will reappear after childbirth.